Data from First and Second PET Scans for Studied Rats
FMZ dose (μg) | |||||
Characteristic | 4 | 20 | 100 | 400 | All doses (μg) |
No. of animals (n)* | |||||
Controls | 5 | 4 | 3 | 2 | 14 |
Kainate | 5 | 6 | 2 | 2 | 15 |
Weight (g) | |||||
Controls | 279 ± 19 | 269 ± 10 | 285 ± 22 | 268 ± 4 | 276 ± 16 |
Kainate | 293 ± 32 | 293 ± 51 | 281 ± 19 | 322 ± 21 | 295 ± 38 |
Scan radioactivity (MBq) | |||||
First | |||||
Controls | 26 ± 3 | 23 ± 8 | 28 ± 3 | 19 ± 1 | 25 ± 5 |
Kainate | 27 ± 6 | 27 ± 5 | 22 ± 3 | 23 ± 2 | 26 ± 5 |
Second | |||||
Controls | 23 ± 7 | 18 ± 2 | 24 ± 7 | 19 ± 3 | 21 ± 5 |
Kainate | 23 ± 6 | 24 ± 9 | 28 ± 3 | 29 ± 5 | 25 ± 7 |
Flumazenil dose (μg) | |||||
First scan | |||||
Controls | 3.5 ± 0.1 | 17 ± 1 | 84 ± 2 | 395 ± 81 | NA |
Kainate | 3.5 ± 0.3 | 18 ± 1 | 79 ± 2 | 422 ± 15 | NA |
Second scan | |||||
Controls | 3.9 ± 0.2 | 18 ± 1 | 88 ± 3 | 424 ± 47 | NA |
Kainate | 3.9 ± 0.2 | 19 ± 1 | 90 ± 3 | 459 ± 0 | NA |
↵* In addition to 29 rats displayed in table, 1 control rat died during surgery and 2 rats died as consequence of kainate treatment.
Values are displayed as average ± SD or n.
NA = not applicable.