TABLE 1

Data from First and Second PET Scans for Studied Rats

FMZ dose (μg)
Characteristic420100400All doses (μg)
No. of animals (n)*
 Controls543214
 Kainate562215
Weight (g)
 Controls279 ± 19269 ± 10285 ± 22268 ± 4276 ± 16
 Kainate293 ± 32293 ± 51281 ± 19322 ± 21295 ± 38
Scan radioactivity (MBq)
 First
  Controls26 ± 323 ± 828 ± 319 ± 125 ± 5
  Kainate27 ± 627 ± 522 ± 323 ± 226 ± 5
 Second
  Controls23 ± 718 ± 224 ± 719 ± 321 ± 5
  Kainate23 ± 624 ± 928 ± 329 ± 525 ± 7
Flumazenil dose (μg)
 First scan
  Controls3.5 ± 0.117 ± 184 ± 2395 ± 81NA
  Kainate3.5 ± 0.318 ± 179 ± 2422 ± 15NA
 Second scan
  Controls3.9 ± 0.218 ± 188 ± 3424 ± 47NA
  Kainate3.9 ± 0.219 ± 190 ± 3459 ± 0NA
  • * In addition to 29 rats displayed in table, 1 control rat died during surgery and 2 rats died as consequence of kainate treatment.

  • Values are displayed as average ± SD or n.

  • NA = not applicable.