TABLE 1

Dosimetry Calculations

			Week 1 after virus injection							Week 2 after virus injection
				¹²⁴I			¹³¹I				¹²⁴I			¹³¹I
				Effective half-time (h)			Effective half-time (h)				Effective half-time (h)			Effective half-time (h)
Method	Mouse no.	Hour	Uptake (%ID/g)	1	2	Absorbed dose in Gy/MBq*	1	2	Absorbed dose in Gy/MBq*	Uptake (%ID/g)	1	2	Absorbed dose in Gy/MBq*	1	2	Absorbed dose in Gy/MBq*
Intravenous	1	1	9.26	7.39	65.08	181 (489)	7.68	98.21	188 (509)	11.14	5.65	53.48	192 (520)	5.82	73.99	196 (531)
		4	8.10							9.95
		8	5.86							8.33
		24	1.75							0.84
		48	0.20							0.09
		72	0.07							0.04
	2	1	7.52	2.54	15.17	115 (312)	2.58	16.46	120 (324)	9.13	7.39	65.08	180 (487)	7.68	98.21	185 (499)
		4	4.55							7.84
		8	2.43							5.71
		24	1.18							1.12
		48	0.50							0.12
		72	0.10							0.05
Intratumoral	3	1	11.58	3.35	65.08	112 (304)	3.41	98.21	116 (313)	8.04	4.63	65.08	101 (273)	4.74	98.20	105 (285)
		4	6.86							4.99
		8	2.53							3.15
		24	0.31							0.41
		48	0.04							0.06
		72	0.03							0.03
	4	1	10.03	4.75	16.57	167 (452)	4.87	18.12	171 (461)	8.05	7.39	65.08	150 (407)	7.68	98.21	155 (420)
		4	8.89							6.73
		8	5.55							5.01
		24	1.24							1.09
		48	0.18							0.13
		72	0.08							0.05

* Data in parentheses are absorbed doses in rad/mCi.