Whole cohort | Men | Women | ||||
Factor | HR | P | HR | P | HR | P |
Pairwise analysis* | ||||||
Age | 2.53 (1.55–4.12) | <0.001 | 3.43 (1.93–6.01) | <0.001 | 1.31 (0.48–3.54) | 0.600 |
Sex | 2.71 (1.66–4.42) | <0.001 | Not applicable | Not applicable | ||
ECOG | 2.30 (1.41–3.66) | 0·001 | 3.08 (1.73–5.47) | <0.002 | 1.13 (0.415–3.06) | 0.816 |
Smoking | 2.53 (1.54–4.16) | <0.001 | 3.46 (1.96–6.12) | <0.001 | 1.14 (0.40–3.28) | 0.807 |
Histology | 2.32 (1.42–3.78) | 0·001 | 2.96 (1.65–5.30) | <0.001 | 1.17 (0.43–3.15) | 0.757 |
Tumor grade | 2.27 (1.37–3.75) | 0.001 | 3.25 (1.82–5.81) | <0.001 | 0.94 (0.31–2.76) | 0.908 |
Pathologic TNM stage | 2.031 (1.22–3.38) | 0.006 | 2.96 (1.58–5.56) | 0.001 | 1.05 (0.39–2.83) | 0.928 |
Diameter | 2.28 (1.34–3.87) | 0.002 | 3.9 (1.81–6.33) | <0.001 | 1.06 (0.36–3.09) | 0.912 |
Vascular invasion | 2.27 (1.38–3.74) | 0.001 | 3.21 (1.81–5.72) | <0.001 | 0.92 (0.33–2.56) | 0.866 |
Lymphatic invasion | 2.24 (1.36–3.68) | 0.002 | 3.27 (1.83–5.85) | <0.001 | 0.85 (0.31–2.34) | 0.749 |
Neural invasion | 2.43 (1.49–3.96) | <0.001 | 3.37 (1.91–5.96) | <0.001 | 0.99 (0.36–2.73) | 0.99 |
Diabetes | 2.51 (1.54–4.09) | <0.001 | 3.44 (1.94–6.07) | <0.001 | 1.05 (0.38–2.87) | 0.932 |
Multivariate analysis† | 1.70 (1.05–2.99) | 0.050 | 2.40 (1.32–4.37) | 0.004 | 0.80 (0.15–4.47) | 0.800 |