TABLE 1

Effects of Inhibitors of Serotonin Pathway on Uptake of 11C-Hydroxytryptophan in PANC-1 and CM Cells

11C-hydroxytryptophan uptake
InhibitorTarget enzyme/transportersPANC-1CM
5-hydroxytryptophanLATStrongly decreasedStrongly decreased
BCHLATStrongly decreasedDecreased
PCPATPHUnchangedDecreased
CarbidopaAADCUnchangedUnchanged
PargylineMAO-A/BUnchangedUnchanged
ClorgylineMAO-AMildly IncreasedStrongly increased
TetrabenazineVMAT2UnchangedIncreased
PCPA + carbidopaTPH + AADCUnchangedDecreased
PCPA + clorgylineTPH + MAO-AUnchangedUnchanged