Assessment of Skeletal Metastasis by 18F-FDG PET/CT and18F-Fluoride PET/CT Based on Lesion Number
| Modality | FN | TP | TN | FP | Sensitivity | Specificity | PPV | NPV | Accuracy | AUC |
| 18F-FDG PET | 43 | 55 | 303 | 2 | 56.1 (45.7–66.1) | 99.3 (97.7–99.9) | 96.5 (87.9–99.6) | 87.6 (83.6–90.9) | 88.8 (85.3–91.7) | 0.7918 (0.73492–0.84877) |
| 18F-FDG PET/CT | 42 | 56 | 305 | 0 | 57.1 (46.7–67.1) | 100.0 | 100.0 | 87.9 (84.0–91.1) | 89.6 (86.2–92.4) | 0.7959 (0.73897–0.85284) |
| 18F-fluoride PET | 33 | 65 | 288 | 16 | 65.7 (55.4–74.9) | 94.7 (91.6–97.0) | 80.2 (69.9–88.3) | 89.4 (85.6–92.6) | 87.6 (84.0–90.6) | 0.7285 (0.64436–0.81263) |
| 18F-fluoride PET/CT | 30 | 68 | 302 | 3 | 69.4 (59.3–78.3) | 99.0 (97.2–99.8) | 95.8 (88.1–99.1) | 91.0 (87.4–93.8) | 91.8 (88.7–94.3) | 0.7561 (0.67382–0.83845) |
| Combined interpretation | 11 | 87 | 302 | 3 | 88.8 (80.8–94.3) | 99.0 (97.2–99.8) | 96.7 (90.6–99.3) | 96.5 (93.8–98.2) | 96.5 (94.2–98.1) | 0.9187 (0.87033–0.96700) |
FN = false negative; TP = true positive; TN = true negative; FP = false positive; PPV = positive predictive value; NPV = negative predictive value.
Data in parentheses are 95% confidence intervals.