TABLE 2

Biodistribution Studies of ¹⁸F-(2S,4R)4F-GLN and ¹⁸F-(2S,4R)4F-GLU in Rats Bearing 9L Tumor After Intravenous Injection

	30 min		60 min
Organ	¹⁸F-(2S,4R)4F-GLU	¹⁸F-(2S,4R)4F-GLN^*	¹⁸F-(2S,4R)4F-GLU	¹⁸F-(2S,4R)4F-GLN^*
Blood	0.36 ± 0.03	0.43 ± 0.01	0.17 ± 0.02	0.32 ± 0.02
Heart	0.16 ± 0.07	0.36 ± 0.02	0.09 ± 0.04	0.35 ± 0.01
Muscle	0.12 ± 0.07	0.37 ± 0.02	0.03 ± 0.02	0.38 ± 0.03
Lung	0.37 ± 0.34	0.64 ± 0.02	0.17 ± 0.06	0.41 ± 0.04
Kidney	3.04 ± 0.02	1.02 ± 0.12	0.99 ± 0.34	0.76 ± 0.18
Pancreas	0.20 ± 0.10	2.14 ± 0.27	0.13 ± 0.09	1.36 ± 0.16
Spleen	0.53 ± 0.22	0.76 ± 0.05	0.34 ± 0.23	0.53 ± 0.04
Liver	0.55 ± 0.12	0.98 ± 0.15	0.39 ± 0.04	0.66 ± 0.13
Skin	0.28 ± 0.05	0.42 ± 0.11	0.16 ± 0.01	0.29 ± 0.04
Brain	0.05 ± 0.01	0.11 ± 0.01	0.05 ± 0.00	0.13 ± 0.00
Bone	1.57 ± 0.44	0.78 ± 0.13	2.03 ± 0.64	1.03 ± 0.38
9L tumor	0.79 ± 0.16	1.03 ± 0.14	0.35 ± 0.25	0.76 ± 0.21
Tumor/blood	2.18 ± 0.47	2.40 ± 0.33	2.11 ± 1.52	2.38 ± 0.67
Tumor/muscle	6.36 ± 3.92	2.78 ± 0.41	11.2 ± 10.9	2.00 ± 0.57
Tumor/brain	17.6 ± 5.02	9.36 ± 1.53	7.13 ± 5.09	5.85 ± 1.61

↵* Data were first published by Lieberman et al. (24).
Data are average percentage dose per gram, mean ± SD (n = 3 to 6).