Characteristics of Bone, Liver, and Other Lesions Before Treatment with 177Lu-Octreotate and at Time of Best Response
| Characteristic | Baseline | Best response | P |
| Bone lesions | n = 64 | n = 61 | |
| Aspect | |||
| Small sclerotic rim | 29 | 28 | |
| Larger sclerotic area | 29 | 27 | |
| Vague sclerotic area with sclerotic rim inside | 2 | 2 | |
| Lytic lesion with sclerotic rim | 4 | 4 | |
| Boundary of lesion (n = 61) | |||
| Well demarcated | 28 | 53 | <0.001* |
| Moderately or poorly demarcated | 33 | 8 | |
| HUs (mean ± SEM) | 423 ± 28 | 447 ± 31 | 0.10 |
| Elevated levels of 5-HIAA at baseline† | |||
| Yes (n = 40) | 412 ± 35 | 444 ± 37 | 0.047* |
| No (n = 20) | 419 ± 44 | 421 ± 51 | 0.96 |
| Treatment outcome | |||
| PR (n = 24) | 378 ± 44 | 392 ± 48 | 0.54 |
| SD (n = 32) | 456 ± 41 | 490 ± 45 | 0.11 |
| PD (n = 2) | 525 ± 83 | 476 ± 3 | 0.67 |
| Unknown (n = 3) | 359 ± 68 | 401 ± 38 | 0.30 |
| Location of primary tumor | |||
| Lung (n = 26) | 463 ± 42 | 503 ± 44 | 0.13 |
| Small intestine (n = 11) | 262 ± 42 | 271 ± 35 | 0.66 |
| Colon/rectum (n = 2) | 689 ± 241 | 740 ± 310 | 0.60 |
| Other (n = 8) | 569 ± 80 | 609 ± 87 | 0.51 |
| Unknown (n = 14) | 354 ± 48 | 347 ± 53 | 0.73 |
| Liver lesions | n = 103 | n = 78 | |
| Homogeneous (n = 78) | |||
| Yes | 46 | 50 | 0.50 |
| No | 32 | 28 | |
| Aspect heterogeneity | |||
| Small dense area on side | 6 | 3 | |
| Hypodense irregularly shaped area in middle | 17 | 9 | |
| Small hypodense area on side | 11 | 11 | |
| Dense irregularly shaped area in middle | 3 | 5 | |
| Density of lesion | |||
| Hypodense | 88 | 65 | |
| Hyperdense | 5 | 3 | |
| Isodense | 2 | 1 | |
| Mixed‡ | 8 | 9 | |
| Boundary of lesion (n = 78) | |||
| Well demarcated | 60 | 48 | 0.04* |
| Moderately or poorly demarcated | 18 | 30 | |
| HUs (mean ± SEM) | 69 ± 2 | 64 ± 3 | 0.70 |
| Treatment outcome | |||
| PR (n = 30) | 74 ± 4 | 61 ± 4 | 0.03* |
| SD (n = 39) | 66 ± 3 | 66 ± 4 | 1.00 |
| PD (n = 4) | 87 ± 1 | 73 ± 5 | 0.05 |
| Unknown (n = 5) | 44 ± 9 | 52 ± 5 | 0.18 |
| Location of primary tumor | |||
| Lung (n = 21) | 62 ± 5 | 70 ± 4 | 0.08 |
| Small intestine (n = 17) | 80 ± 4 | 58 ± 6 | <0.001* |
| Colon/rectum (n = 10) | 80 ± 6 | 50 ± 3 | 0.001* |
| Other (n = 1) | 54 (NA) | 56 (NA) | NA |
| Unknown (n = 29) | 63 ± 4 | 68 ± 5 | 0.22 |
| Other lesions | n = 3 | n = 3 | |
| Boundary of lesion | |||
| Well demarcated | 2 | 3 | 1.00 |
| Moderately or poorly demarcated | 1 | 0 | |
| HUs (mean ± SEM) | 91 ± 4 | 91 ± 27 | 0.99 |
↵* Significant difference (McNemar test for boundary lesion, paired t test for HUs).
↵† In 1 patient 5-HIAA level was not determined at baseline.
↵‡ Combination of hypodense, hyperdense, or isodense.
NA = not applicable.
Elevated 5-HIAA is ≥50 μmol/L in 24-h urine collection. Numbers in italics are numbers of patients used for McNemar test (some lesions disappeared at best response, and some lesions were not imaged by CT scan; only paired data were used).