TABLE 2.

Biodistribution Results of 68Ga-DOTATATE in Nude Mice Bearing HEK-hsst2 Tumor Xenografts

Organ1 h1-h blocking*2 h
Blood0.4 ± 0.00.8 ± 0.10.3 ± 0.0
Heart0.2 ± 0.00.3 ± 0.00.2 ± 0.0
Liver0.4 ± 0.20.5 ± 0.10.3 ± 0.0
Spleen0.540.20.4 ± 0.00.4 ± 0.1
Lung2.4 ± 0.70.8 ± 0.02.4 ± 0.4
Kidney5.2 ± 0.97.3 ± 1.64.7 ± 0.9
Stomach8.6 ± 1.90.5 ± 0.15.5 ± 0.6
Intestine0.8 ± 0.10.4 ± 0.21.00 ± 0.1
Adrenal2.8 ± 0.50.6 ± 0.13.6 ± 1.0
Pancreas10.8 ± 1.70.4 ± 0.17.2 ± 1.8
Muscle0.4 ± 0.00.3 ± 0.10.4 ± 0.2
Bone0.7 ± 0.30.5 ± 0.11.1 ± 0.5
Tumor17.8 ± 2.22.2 ± 0.418.5 ± 5.8
Tumor–to–normal tissue ratios
 Tumor to blood40.466.2
 Tumor to liver41.361.8
 Tumor to kidney3.44.0
 Tumor to muscles50.842.1
  • * Coinjection with 1,500-fold excess of DOTATATE.

  • Data are %IA/g ± SD, n = 3–5.