TABLE 4.

Biodistribution Results of 68Ga-NODAGA-JR11 in Nude Mice Bearing HEK-hsst2 Tumor Xenografts

Organ1 h1-h blocking*2 h
Blood0.5 ± 0.21.4 ± 0.20.3 ± 0.2
Heart0.3 ± 0.10.9 ± 0.40.1 ± 0.0
Liver0.6 ± 0.11.2 ± 0.10.4 ± 0.1
Spleen0.7 ± 0.41.4 ± 0.20.4 ± 0.0
Lung2.7 ± 0.73.1 ± 0.60.9 ± 0.1
Kidney10.4 ± 1.413.6 ± 0.310.5 ± 1.2
Stomach9.9 ± 2.51.6 ± 0.83.1 ± 0.4
Intestine0.7 ± 0.21.0 ± 0.50.4 ± 0.1
Adrenal1.5 ± 0.4Not determined1.6 ± 0.2
Pancreas11.4 ± 3.60.5 ± 0.03.8 ± 0.3
Muscle0.2 ± 0.00.7 ± 0.20.2 ± 0.1
Bone0.8 ± 0.11.1 ± 0.10.7 ± 0.2
Tumor30.7 ± 1.62.5 ± 0.031.6 ± 3.5
Tumor-to-normal tissue ratios
 Tumor to blood57.9105.2
 Tumor to liver49.580.9
 Tumor to kidney3.03.0
 Tumor to muscles153.5166.1
  • * Coinjection with 1,500-fold excess of NODAGA-JR11.

  • Data are %IA/g ± SD, n = 3–5.