TABLE 1

Baseline Characteristics of Patients With and Without Bone Lesions Visible on CT Before Treatment with 177Lu-Octreotate

CharacteristicBone lesions visible on CTBone lesions not visible on CTP
No. of patients3111
No. of male patients1971.00
Age (y)0.85
Mean6162
Range43–7751–79
Time from diagnosis to treatment (mo)0.91
Median1643
Range4–3543–313
Time from development of bone metastases to treatment (mo)0.51
Median43
Range1–441–14
Location of primary tumor (n)
Lung1100.01*
Small intestine57
Colon/rectum20
Other40
Unknown94
Previous therapy (n)2580.68
Octreotide2080.72
Surgery1670.73
Radiotherapy420.64
Chemotherapy311.00
Embolization/chemoembolization311.00
Liver radiofrequency ablation101.00
Total administered dose (GBq)0.50
Median29.729.9
Range22.0–30.214.7–30.3
5-HIAA elevated (n)1890.28
  • * Significant difference (Fisher exact test using Monte Carlo method).

  • Elevated 5-HIAA is ≥50 μmol/L in 24-h urine collection.