Baseline Characteristics of Patients With and Without Bone Lesions Visible on CT Before Treatment with 177Lu-Octreotate
Characteristic | Bone lesions visible on CT | Bone lesions not visible on CT | P |
No. of patients | 31 | 11 | |
No. of male patients | 19 | 7 | 1.00 |
Age (y) | 0.85 | ||
Mean | 61 | 62 | |
Range | 43–77 | 51–79 | |
Time from diagnosis to treatment (mo) | 0.91 | ||
Median | 16 | 43 | |
Range | 4–354 | 3–313 | |
Time from development of bone metastases to treatment (mo) | 0.51 | ||
Median | 4 | 3 | |
Range | 1–44 | 1–14 | |
Location of primary tumor (n) | |||
Lung | 11 | 0 | 0.01* |
Small intestine | 5 | 7 | |
Colon/rectum | 2 | 0 | |
Other | 4 | 0 | |
Unknown | 9 | 4 | |
Previous therapy (n) | 25 | 8 | 0.68 |
Octreotide | 20 | 8 | 0.72 |
Surgery | 16 | 7 | 0.73 |
Radiotherapy | 4 | 2 | 0.64 |
Chemotherapy | 3 | 1 | 1.00 |
Embolization/chemoembolization | 3 | 1 | 1.00 |
Liver radiofrequency ablation | 1 | 0 | 1.00 |
Total administered dose (GBq) | 0.50 | ||
Median | 29.7 | 29.9 | |
Range | 22.0–30.2 | 14.7–30.3 | |
5-HIAA elevated (n) | 18 | 9 | 0.28 |
↵* Significant difference (Fisher exact test using Monte Carlo method).
Elevated 5-HIAA is ≥50 μmol/L in 24-h urine collection.