TABLE 5.

Comparison of Multiple Uptake Parameters at Multiple Imaging Time Points in Patients with Prostate Cancer

	Imaging time point
Parameter	1	2	3	4	5
Time (min)	12.9 ± 2.8	35.3 ± 3.7	57.9 ± 4.7	123.6 ± 7.2	184.8 ± 9.8
Interval (min)		22.40	22.60	65.70	61.20
Global
SUV10_{mean (log-scale)}	2.73	2.77	2.75	2.69	2.6
Mean difference (log-scale)		0.04	<0.01	−0.03	−0.02
Percentage change/min^*		0.3	<0.1	−0.1	<0.01
P		0.0016	0.7708	0.1154	0.1832
SUV10_act	5.8	6.59	6.6	7.35	7.64
Mean difference (log-scale)		0.79	0.41	0.85	0.51
Percentage change/min^*		5.3	1.4	1.4	0.9
P		<0.0001	<0.0001	<0.0001	<0.0001
Malignant
mSUV10_max	3.63	3.84	3.93	4.1
Mean difference (log-scale)		0.24	0.09	0.24
Percentage change/min (log-scale)		1.6	0.3	0.4
P		<0.0001	<0.0001	<0.0001
mSUV10_mean	2.85	2.94	3	3.02
Mean difference (log-scale)		0.11	0.06	0.05
Percentage change/min^*		0.7	0.2	0.1
P		<0.0001	<0.0001	0.0365
mSUV10_act	6.94	7.2	7.41	7.34
Mean difference (log-scale)		0.44	0.2	0.43
Percentage change/min^*		3	0.7	0.7
P		<0.0001	<0.0001	<0.0001
Normalized
mSUV10_max:bkg
Mean difference (log-scale)		0.08	0.01	0.04
Percentage change/min^*		0.5	<0.1	0.1
P		0.0386	0.8362	0.4001
mSUV10_act:bkg
Mean difference (log-scale)		0.28	0.11	0.22
Percentage change/min^*		1.9	0.4	0.4
P		0	0.0004	0.0032

↵* Percentage change per minute values is identical for both log and original scales.
Time interval between time points 3 and 4 and 4 and 5 is approximately 3 times that of 1–2 and 2–3. SUV10_mean and SUV10_act represent mean SUV and total ¹⁸F-NaF activity of VOI containing all bone with SUV ≥10, respectively.