TABLE 1

Definition of PET Parameters

ParameterDescription
GlobalUsed in all patients
 SUV10meanMean SUV of a VOI including all bony areas with SUV ≥ 10
 SUV10actTotal activity of 18F-NaF in all bone uptake with SUV ≥ 10
 bkgMean SUV of noninvolved bone (a vertebral body when available); normal bone background
MalignantUsed only in prostate patients with malignant lesions
 mSUV10maxMaximum SUV of all malignant lesions with SUV ≥ 10
 mSUV10meanAverage SUV10mean of all malignant lesions with SUV ≥ 10
 mSUV10actTotal 18F-NaF activity in all malignant lesions with SUV ≥ 10 (an estimate of total metastatic burden)
NormalizedUsed only in prostate patients with malignant lesions
 mSUV10max:bkgMaximum SUV of all malignant lesions divided by mean SUV of normal bone
 mSUV10act:bkgTotal activity in all malignant lesions divided by mean SUV of normal bone