Patient no. | Age (y) | Sex | Kadish stage at time of examination | PET/CT | Number/type conventional imaging | Anatomic site of discordance | Clinical impact |
1 | 50 | M | D | Restaging | 2 MRI | Levels I and II | TP, bilateral radical neck dissection |
2 | 5 | F | D | Restaging | 1 MRI | Level I | TP, selective neck dissection |
3 | 5 | F | D | Restaging | 1 MRI/1CT | Level I | TP, selective neck dissection |
4 | 46 | M | D | Restaging | 1 MRI | Levels I, II, III, and IV, RPLN | TP, bilateral modified neck dissection |
4 | 47 | M | D | Restaging | 1 MRI | R PPF | TP, γ-knife therapy |
5 | 66 | F | D | Restaging | 2 MRI | Level II/lumbar epidural | TP, prompted LN Bx; palliative spinal XRT given carcinomatosis |
6 | 44 | F | D | Restaging | 1 MRI | Distant osseous | TP, palliative radiation |
6 | 45 | F | D | Restaging | 1 MRI | Distant osseous | TP, palliative radiation |
6 | 44 | F | D | Restaging | 1 MRI | Distant osseous | TP, prompted bone Bx; treatment changed to salvage chemotherapy |
7 | 44 | M | C | Staging | 1 MRI/1 CT | Level II | TP, systemic chemotherapy given stage C primary |
7 | 44 | M | D | Restaging | 2 MRI | Level II | TP, prompted Bx; neoadjuvant chemotherapy |
8 | 70 | M | D | Restaging | 3 MRI | Maxillary sinus | TP, prompted Bx; conservative management |
9 | 42 | M | D | Restaging | 1 CT | Level I/distant osseous | TP, conservative management |
4 | 48 | M | D | Restaging | 2 MRI | L PPF/infraclavicular LN | TP, palliative care |
10 | 80 | F | D | Restaging | 1 MRI | ACF | FN, therapy based on MRI |
10 | 81 | F | D | Restaging | 2 MRI | ACF | FN, therapy based on MRI |
11 | 37 | F | C | Restaging | 1 CT/1 MRI | ACF | FN, therapy based on MRI |
12 | 48 | M | C | Restaging | 2 MRI | Frontal/parietal dura | FN, therapy based on MRI |
4 | 47 | M | D | Restaging | 1 MRI | Ethmoid sinus | FN, therapy based on MRI |
13 | 40 | F | B | Restaging | 1 MRI | L sphenoid/ethmoid | FN, therapy based on MRI |
14 | 50 | M | C | Staging | 1 MRI | Level III | FP, pathology showed reactive node |
14 | 50 | M | C | Restaging | 1 MRI | Cribriform plate/ACF | TN, MRI false-positive; no recurrence to date |
TP = true-positive; RPLN = retropharyngeal lymph node; PPF = pterygopalatine fossa; LN = lymph node; Bx = biopsy; XRT = radiation therapy; ACF= anterior cranial fossa; FN = false-negative; FP = false-positive; TN = true-negative.