TABLE 1

Summary of Lesions in EAE and HC Animals

Animal no.	MRI	Location of cellular infiltrates	¹⁸F-FDG PET
EAE
1	Pons right side−, T4–L5+	Cerebellum, pons, C1, C4–C7, T2–T5, T8–T9, T11–conus	C1+, C6+, T1–T2+, T4–T5+, T9–T10++, T11–L1+++
2	Periventricular left side, pons right side, T12–L1: no gadolinium application	Cerebellum, pons, C1, C5–conus	Brain stem/cerebellum left side++, C1+, C5+, T8–T9++, T11–T12++, T13+, L1++
3	Medulla oblongata dorsal–C3, C4–T1, T5–L2: no gadolinium application	Cerebellum, T1–conus	C7–T4++, T10–L2+++
4	Pontomesencephalic brain stem dorsal left side+, Vermis+, T1 to T5+, T10/11+, T13–L5+	Cerebellum, pons, C1–T3, T6–T10, T12–conus	Brain stem and cerebellum+, C1–C2+, C6–C7+, T12–L2++
5	T3 to T5−, T10–L1++, L2/3+	Pons, T2–3, T5, T6–conus	T2+, T5+, T9+, T11–L2+++
6	Vermis caudal+, T6+, T8+, T11−, T12/13+, T13–L1+, L1–L2+, L2–L 3+	Not done^*	Brain stem/cerebellum++, T1–T3++, T9+, T10+, T11–L2++
7	Cerebellum right side+, T8–L4+	Not done^*	C6–T3+, L1–L4+++
8	Vermis−, L1 to 3−, L3 to 5−	Not done^*	T11+, T12+, L2/3++, L4+
9	None	Not done^*	T1+, T11+, T12–L1++
10	T2–T7+, T13–L1++	Not done^*	T4–T6+, T13–L1++
11	T4 to 5−, T8–L2+, L4 to 5−	Not done^*	T1+, T5+, T8–L1+++, L2+
12	Mesencephalon left side−, pons left side+, T5++, T8/9+.	Not done^*	T13–L1+
13	T12 to L1−	Not done^*	T12–T13+, L1+
HC
1	None	None	None
2	None	None	None
3	None	None	None
4	None	Not done^*	None
5	None	Not done^*	None
6	None	Not done^*	None

↵* Used for RNA expression analysis.
Localization of lesions was determined in descriptive manner for MRI, histology, and ¹⁸F-FDG PET/CT. For MRI, lesions were categorized as without contrast enhancement (−), with contrast enhancement being present (+), or with strong contrast enhancement (++). The PET signal was classified as mild (+), moderate (++), or strong (+++). If there is no side specified, lesion is central or within whole cross-section.
C = cervical spinal cord; T = thoracic spinal cord; L = lumbar spinal cord.