MRI Volumetry in SCA17
| Symptomatic | Presymptomatic | |||||
| Parameter | SCA17 | Controls | P | SCA17 | Controls | P |
| Age (y) | 48.0 (43–49) | 58.3 (57–62) | 0.024 | 39.5 (27–46) | 52.7 (50–55) | 0.034 |
| Intracranial volume (total) | 1,603.0 (1,339.4–1,702.5) | 1,429.9 (1,345.6–1,578.0) | 0.37 | 1,434.4 (1,234.6–1,439.2) | 1,434.9 (1,376.8–1,529.4) | 0.86 |
| Frontal lobe (average) | 163.5 (142.8–192.8) | 155.2 (152.0–155.8) | 0.30 | 159.1 (133.2–161.2) | 164.5 (161.6–166.5) | 0.63 |
| Temporal lobe (average) | 145.0 (111.2–172.5) | 138.5 (130.9–138.7) | 0.17 | 120.6 (100.3–132.1) | 151.4 (138.8–158.3) | 0.19 |
| Parietal lobe (average) | 146.7 (121.2–186.3) | 180.3 (159.4–180.7) | 0.18 | 148.2 (143.5–170.5) | 163.5 (150.9–186.7) | 0.48 |
| Occipital lobe (average) | 30.8 (27.5–41.4) | 40.2 (38.5–43.7) | 0.22 | 30.0 (28.4–38.4) | 35.5 (35.3–40.3) | 0.14 |
| Putamen (average) | 1.9 (1.7–4.1) | 3.8 (3.6–4.0) | 0.13 | 2.9 (2.9–3.8) | 4.1 (3.0–4.1) | 0.24 |
| Caudate nucleus (average) | 2.0 (1.5–4.3) | 3.9 (3.7–4.1) | 0.05 | 2.5 (2.3–3.4) | 4.1 (3.9–4.1) | 0.01 |
| Brain stem | 25.4 (24.7–36.1) | 31.9 (31.4–34.9) | 0.06 | 30.6 (24.8–30.9) | 33.0 (29.9–34.2) | 0.64 |
| Pons | 16.0 (15.2–24.7) | 20.0 (19.9–23.1) | 0.06 | 20.0 (16.7–21.6) | 20.0 (19.6–21.2) | 0.57 |
| Medulla | 6.2 (5.7–6.6) | 7.9 (7.5–8.1) | 0.08 | 5.5 (5.1–7.5) | 8.7 (5.4–8.8) | 0.62 |
| Cerebellum (total) | 85.6 (67.3–122.4) | 122.8 (118.3–132.4) | 0.05 | 114.4 (108.2–130.5) | 127.1 (125.9–127.5) | 0.14 |
| Cerebellar hemisphere, right | 38.5 (30.3–55.5) | 52.9 (52.3–56.7) | 0.08 | 51.2 (48.7–58.6) | 54.3 (53.3–55.4) | 0.20 |
| Cerebellar hemisphere, left | 38.8 (29.4–53.5) | 55.5 (52.2–61.3) | 0.04 | 49.7 (49.5–56.1) | 54.7 (54.3–55.7) | 0.04 |
| Cerebellar vermis | 8.3 (7.6–13.4) | 14.4 (13.8–18.4) | 0.02 | 13.6 (10.0–15.9) | 17.1 (16.1–19.5) | 0.28 |
Data are median, with range in parentheses, and were compared with matched controls. Volume data are in cubic centimeters.