Nonhematologic Toxicities Related to Therapy
Maximum toxicity grade experienced | |||||
Administered dose level | Toxicity category | 1 | 2 | 3 | 4 |
444 MBq/kg (n = 5) | Hepatic | 3 | 1 | 0 | 0 |
Constitutional | 0 | 1 | 0 | 0 | |
Infection/febrile neutropenia | 0 | 0 | 1 | 0 | |
Pain | 2 | 0 | 0 | 0 | |
Gastrointestinal | 2 | 0 | 0 | 0 | |
Metabolic/laboratory | 2 | 0 | 0 | 0 | |
Neurology | 1 | 0 | 0 | 0 | |
555 MBq/kg (n = 3) | Hepatic | 1 | 1 | 0 | 0 |
Pain | 0 | 2 | 0 | 0 | |
Gastrointestinal | 0 | 1 | 0 | 0 | |
Dermatology/skin | 0 | 1 | 0 | 0 | |
Metabolic/laboratory | 1 | 0 | 0 | 0 | |
Neurology | 1 | 0 | 0 | 0 | |
666 MBq/kg (n = 7) | Hepatic | 4 | 2 | 0 | 0 |
Constitutional | 2 | 1 | 0 | 0 | |
Cardiovascular | 1 | 0 | 0 | 0 | |
Infection/febrile neutropenia | 0 | 0 | 2 | 0 | |
Pain | 2 | 3 | 0 | 0 | |
Gastrointestinal | 1 | 4 | 0 | 0 |