Technical Requirements, Automation, and Robustness of Different 18F-FDG PET Global Indices Involved in This Head-to-Head Comparison
| Characteristic | PALZ | metaROI | HCI |
| Software required | PMOD | Matlab, SPM | Matlab, SPM, HCI package |
| Additional requirements | — | 5 metaROIs, pons/cerebellar vermis ROI | Normative dataset, AD z score map |
| Automation | High | Medium | High |
| Supported image formats | DICOM, ECAT, Analyze, NIFTI, and others | Analyze, NIFTI | Analyze, NIFTI |
| Robustness | Slight change with image format; preliminary reorientation to anatomic position needed (formats other than DICOM) | No change with image format; automatic reorientation to anatomic position | No change with image format, automatic reorientation to anatomic position |
SPM = statistical parametric mapping.