ROI Analysis
| Region | Placebo NGM | Endotoxin NGM | Mean % difference | F1,40 | F1,88 | F1,56 | Uncorrected P | Corrected P |
| Primary | ||||||||
| Amygdala | 0.72 ± 0.07 | 0.71 ± 0.07 | −0.5 ± 11 | 0.1 | 0.79 | 1 | ||
| Cingulate | 1.24 ± 0.07 | 1.21 ± 0.06 | −2.5 ± 3.2 | 5.8 | 0.020 | 0.060 | ||
| Insula | 1.19 ± 0.03 | 1.23 ± 0.02 | 3.0 ± 3.6* | 6.3 | 0.016 | 0.048* | ||
| Subregions | ||||||||
| Cingulate | ||||||||
| Anterior right | 1.23 ± 0.06 | 1.17 ± 0.07 | −4.5 ± 2.7* | 14.6 | 0.0002 | 0.0012* | ||
| Anterior left | 1.23 ± 0.10 | 1.25 ± 0.07 | 2.0 ± 4.4 | 2.2 | 0.14 | 0.84 | ||
| Middle right | 1.30 ± 0.07 | 1.26 ± 0.08 | −3.4 ± 6.3 | 3.4 | 0.07 | 0.42 | ||
| Middle left | 1.23 ± 0.12 | 1.20 ± 0.08 | −2.3 ± 5.3 | 1.7 | 0.20 | 1 | ||
| Posterior right | 1.25 ± 0.13 | 1.19 ± 0.17 | −4.3 ± 11 | 1.2 | .27 | 1 | ||
| Posterior left | 1.01 ± 0.14 | 0.99 ± 0.22 | −2.8 ± 18 | 0.3 | 0.60 | 1 | ||
| Insula | ||||||||
| Anterior right | 1.24 ± 0.08 | 1.30 ± 0.06 | 5.4 ± 9.1 | 5.7 | 0.0204 | 0.082 | ||
| Anterior left | 1.26 ± 0.05 | 1.29 ± 0.05 | 2.8 ± 4.3 | 1.7 | 0.198 | 0.79 | ||
| Posterior right | 1.08 ± 0.08 | 1.12 ± 0.07 | 4.2 ± 6.5 | 2.4 | 0.124 | 0.50 | ||
| Posterior left | 1.09 ± 0.08 | 1.07 ± 0.10 | −1.9 ± 6.3 | 0.7 | 0.418 | 1 | ||
↵* Differences were considered significant at corrected P < 0.05 level.
Mean values (±SD) for NGM for each region and both conditions are shown. Mean percentage difference was mean of each individual subject's percentage difference between placebo and endotoxin.