Sociodemographic and Clinical Features, 18F-FDG PET Global Indices of Healthy Subjects Included in the Normative Dataset, and Disaggregated by Dataset and Enrollment Center
| Dataset | Center | n | Age (y) | Sex (female) | MMSE | PALZ (t scores) | metaROI (W-scores) | HCI* |
| NEST-DD | Cologne | 19 | 62 ± 4 | 12 (63%) | 29 ± 1 | 4,432 ± 2,147 | 0.55 ± 1.32 | −253 ± 504 |
| Liege | 12 | 64 ± 5 | 7 (58%) | 29 ± 1 | 3,916 ± 6,683 | 0.22 ± 1.28 | −159 ± 450 | |
| Florence | 2 | 60 ± 8 | 0 (0%) | 29 ± 1 | 7,168 ± 8,480 | 1.67 ± 1.71 | 330 ± 899 | |
| Dresden | 2 | 57 ± 11 | 1 (50%) | 29 ± 1 | 5,258 ± 2,340 | −0.53 ± 1.18 | −229 ± 157 | |
| EADC-PET | Brescia | 27 | 65 ± 5 | 14 (52%) | 29 ± 1 | 7,368 ± 6,488 | 0.11 ± 1.89 | 120 ± 601 |
| Genoa | 36 | 69 ± 7 | 24 (67%) | 29 ± 1 | 6,821 ± 3,974 | 0.24 ± 1.98 | 246 ± 639 | |
| Marseilles | 10 | 66 ± 5 | 4 (40%) | 30 ± 0 | 3,160 ± 1,930 | −0.54 ± 1.67 | −73 ± 432 | |
| Munich | 19 | 68 ± 8 | 9 (47%) | 29 ± 1 | 3,464 ± 1,608 | −0.36 ± 1.32 | −265 ± 646 | |
| Amsterdam | 21 | 66 ± 7 | 8 (38%) | 30 ± 1 | 3,982 ± 3,098 | −0.70 ± 1.88 | −2 ± 626 |
↵* HCI, computed as inner product of individual z map and predefined AD z map on all voxels, is expressed in arbitrary units.
Values are mean ± SD for continuous variables, or frequency (followed by percentage in parentheses) for sex.