TABLE 2

Sociodemographic and Clinical Features, 18F-FDG PET Global Indices of Healthy Subjects Included in the Normative Dataset, and Disaggregated by Dataset and Enrollment Center

DatasetCenternAge (y)Sex (female)MMSEPALZ (t scores)metaROI (W-scores)HCI*
NEST-DDCologne1962 ± 412 (63%)29 ± 14,432 ± 2,1470.55 ± 1.32−253 ± 504
Liege1264 ± 57 (58%)29 ± 13,916 ± 6,6830.22 ± 1.28−159 ± 450
Florence260 ± 80 (0%)29 ± 17,168 ± 8,4801.67 ± 1.71330 ± 899
Dresden257 ± 111 (50%)29 ± 15,258 ± 2,340−0.53 ± 1.18−229 ± 157
EADC-PETBrescia2765 ± 514 (52%)29 ± 17,368 ± 6,4880.11 ± 1.89120 ± 601
Genoa3669 ± 724 (67%)29 ± 16,821 ± 3,9740.24 ± 1.98246 ± 639
Marseilles1066 ± 54 (40%)30 ± 03,160 ± 1,930−0.54 ± 1.67−73 ± 432
Munich1968 ± 89 (47%)29 ± 13,464 ± 1,608−0.36 ± 1.32−265 ± 646
Amsterdam2166 ± 78 (38%)30 ± 13,982 ± 3,098−0.70 ± 1.88−2 ± 626
  • * HCI, computed as inner product of individual z map and predefined AD z map on all voxels, is expressed in arbitrary units.

  • Values are mean ± SD for continuous variables, or frequency (followed by percentage in parentheses) for sex.