TABLE 2

11C-(R)-PK11195 Brain Uptake in Control and HSV-1–Infected Rats 5 Days After HSV-1 Inoculation

Region of brainHSV-1 (n = 7)Control (n = 7)
Striatum0.50 ± 0.07*0.40 ± 0.05
Frontal cortex0.67 ± 0.07†0.49 ± 0.07
Parietal/temporal/occipital cortex0.48 ± 0.07*0.40 ± 0.05
Bulbus olfactorius1.19 ± 0.18†0.82 ± 0.09
Cerebellum0.54 ± 0.090.48 ± 0.05
Brainstem0.67 ± 0.19*0.46 ± 0.07
Thalamus0.41 ± 0.04†0.31 ± 0.06
Midbrain0.36 ± 0.060.34 ± 0.09

  • ↵* P < 0.05 compared with control.

  • ↵† P < 0.005 compared with control.

  • Values represent standardized uptake values (mean ± SD) from last 10 min of PET scan.