Tissue | 1 d | 2 d | 3 d | 5 d | 7 d |
Blood | 12.85 ± 1.22 | 8.31 ± 1.63 | 3.63 ± 1.08 | 0.78 ± 0.11 | 0.42 ± 0.06 |
Tumor | 96.58 ± 8.97 | 98.50 ± 15.65 | 53.48 ± 8.41 | 24.23 ± 3.25 | 17.71 ± 3.09 |
Liver | 5.64 ± 0.91 | 6.13 ± 0.80 | 4.85 ± 0.39 | 3.90 ± 0.21 | 4.41 ± 0.37 |
Spleen | 4.98 ± 0.92 | 7.03 ± 1.22 | 3.97 ± 0.47 | 4.85 ± 1.02 | 3.84 ± 0.56 |
Kidney | 4.15 ± 0.28 | 4.49 ± 0.82 | 4.15 ± 0.64 | 3.56 ± 0.21 | 3.70 ± 0.36 |
Lung | 6.07 ± 0.61 | 4.57 ± 0.65 | 2.47 ± 0.62 | 1.14 ± 0.40 | 1.02 ± 0.12 |
Heart | 4.32 ± 0.53 | 2.78 ± 0.46 | 1.40 ± 0.31 | 0.54 ± 0.04 | 0.54 ± 0.06 |
Femur | 3.00 ± 0.37 | 4.76 ± 0.68 | 5.50 ± 0.33 | 6.51 ± 0.72 | 7.00 ± 1.32 |
Tumor/blood | 7.54 ± 0.19 | 12.28 ± 0.62 | 16.76 ± 1.97 | 31.96 ± 2.45 | 41.59 ± 3.87 |
Biodistribution data were obtained at 1, 2, 3, 5, and 7 d after intraperitoneal injection of 89Zr-labeled panitumumab. All values are expressed as %ID/g (except ratios). Data represent mean value ± SEM from at least 5 determinations.