Biodistribution of 89Zr-Labeled Panitumumab in Selected Organs of Female Athymic (NCr) nu/nu Mice Bearing Pulmonary Metastatic Human LS-174T Tumors
| Tissue | 1 d | 2 d | 3 d | 5 d | 5 d (block)* |
| Blood | 19.77 ± 0.06 | 11.11 ± 0.73 | 6.32 ± 1.41 | 3.70 ± 0.42 | 14.11 ± 3.44 |
| Tumor | 59.95 ± 3.15 | 78.05 ± 7.15 | 60.12 ± 6.94 | 61.97 ± 6.02 | 11.61 ± 1.26 |
| Liver | 7.64 ± 0.53 | 6.13 ± 0.88 | 13.64 ± 6.73 | 8.67 ± 0.81 | 6.81 ± 0.72 |
| Spleen | 5.71 ± 0.20 | 4.63 ± 0.45 | 5.68 ± 0.45 | 5.91 ± 1.43 | 5.39 ± 1.28 |
| Kidney | 4.27 ± 0.32 | 3.46 ± 0.13 | 2.97 ± 0.60 | 3.00 ± 0.22 | 3.57 ± 0.41 |
| Lung | 13.86 ± 1.14 | 9.60 ± 1.36 | 7.69 ± 1.42 | 8.56 ± 2.31 | 5.07 ± 1.14 |
| Heart | 4.92 ± 0.31 | 3.56 ± 0.29 | 2.67 ± 0.55 | 1.64 ± 0.08 | 4.50 ± 0.53 |
| Femur | 3.60 ± 0.18 | 4.04 ± 0.14 | 5.07 ± 0.57 | 6.40 ± 0.96 | 3.51 ± 1.03 |
| Tumor/blood | 3.03 ± 0.15 | 7.09 ± 0.64 | 11.07 ± 1.79 | 17.26 ± 2.05 | 0.91 ± 0.17 |
↵* Receptor-blocking studies were performed by coinjecting 0.1 mg of panitumumab with radiolabeled antibody.
Biodistribution data were obtained at 1, 2, 3, and 5 d after intravenous injection of 89Zr-labeled panitumumab. All values are expressed as %ID/g (except ratios). Data represent mean value ± SEM from at least 4 determinations.