TABLE 1

Dose Escalation of ⁸⁹Zr-Fresolimumab and Control ¹¹¹In-IgG

	Dose (μg)
	10 (n = 5)		50 (n = 2)		100 (n = 6)
Organ	⁸⁹Zr-fresolimumab	¹¹¹In-IgG	⁸⁹Zr-fresolimumab	¹¹¹In-IgG	⁸⁹Zr-fresolimumab	¹¹¹In-IgG
Heart	3.47 ± 0.59	3.61 ± 0.57	3.53 ± 0.54	3.88 ± 0.63	4.58 ± 0.66	3.72 ± 0.37
Blood	8.23 ± 1.47	10.71 ± 1.93	9.03 ± 2.32	12.29 ± 2.40	7.79 ± 1.84	10.07 ± 1.50
Lung	7.76 ± 3.98	7.27 ± 2.10	4.99 ± 1.31	5.55 ± 1.14	4.46 ± 1.12	4.72 ± 1.05
Liver	6.31 ± 1.71	4.27 ± 0.96	6.69 ± 1.12	3.49 ± 0.09	8.91 ± 2.21	4.93 ± 1.00
Kidney	8.10 ± 0.75	4.32 ± 0.80	4.37 ± 0.18	3.45 ± 0.40	4.08 ± 0.38	3.79 ± 0.54
Urine	1.91 ± 1.55	1.82 ± 1.16	0.68 ± 0.05	0.94 ± 0.09	1.01 ± 0.41	1.65 ± 0.87
Bladder	4.23 ± 1.15	4.83 ± 0.90	3.16 ± 0.64	3.80 ± 0.71	3.29 ± 0.83	3.39 ± 0.89
Stomach	1.40 ± 0.28	1.47 ± 0.32	1.17 ± 0.05	1.18 ± 0.03	1.39 ± 0.16	1.39 ± 0.12
Pancreas	0.96 ± 0.52	1.08 ± 0.57	1.37 ± 0.36	1.54 ± 0.31	1.14 ± 0.20	1.29 ± 0.19
Spleen	5.22 ± 0.65	5.02 ± 0.71	5.43 ± 0.87	4.88 ± 1.02	5.83 ± 0.39	4.93 ± 0.47
Small intestine	1.38 ± 0.52	1.58 ± 0.71	1.38 ± 0.30	1.57 ± 0.31	1.55 ± 0.66	1.73 ± 0.66
Large intestine	1.48 ± 0.35	1.84 ± 0.58	1.39 ± 0.08	1.63 ± 0.05	1.17 ± 0.21	1.33 ± 0.26
Muscle	1.14 ± 0.40	1.34 ± 0.31	0.98 ± 0.04	1.27 ± 0.05	1.18 ± 0.14	1.31 ± 0.18
Bone	4.05 ± 0.77	2.04 ± 0.39	3.50 ± 0.42	1.75 ± 0.48	2.28 ± 0.81	1.50 ± 0.53
Tumor	5.64 ± 1.80	6.22 ± 2.17	5.99 ± 0.24	7.05 ± 0.71	6.56 ± 1.75	6.76 ± 1.58
Brain	0.23 ± 0.08	0.30 ± 0.10	0.21 ± 0.04	0.26 ± 0.04	0.25 ± 0.09	0.32 ± 0.10

Data are expressed as %ID/g of tissue (mean ± SD).