Benefit Expected from Replacing Current Standard with PET/CT to Decide Between Responders (R) and Nonresponders (N)
| Validity of change | Change | Impact on survival | First source for quantifying benefit |
| Correct | R → N | + | Survival rate under second-line therapy in N (clinical data) |
| Correct | N → R | (+) | Loss of efficacy of first-line therapy because of early discontinuation (clinical data plus expert knowledge) |
| Incorrect | R → N | (−) | Opposite of benefit of correct N → R changes |
| Incorrect | N → R | − | Opposite of benefit of correct R → N changes |
Data show effects of changes in response evaluation: + = improvement; (+) = improvement possible; (−) = decrement possible; − = decrement.