Basic Advantages and Disadvantages of Decision Modeling and RCTs
| Parameter | Decision modeling | RCTs |
| Information on long-term outcomes | Relies on combination of information from different sources | Long-term outcomes can be directly observed |
| Sample size | Requires accuracy study with moderate sample size and information from other studies | Requires inclusion of many patients in trial |
| Unexpected or unintended effects | Cannot be covered | Are covered |