Standard needed for: | |||||
Use of SUV (baseline or residual)* | Use of percentage changes in SUVs (longitudinal studies) | ||||
Factor | Target lesion eligibility | Prognostic factor | Predictive factor | Hottest lesion(s)/scan (PERCIST criteria) | Same lesion(s) for all scans in subject's longitudinal study (EORTC criteria) |
Biologic | |||||
Uptake period | H | H | H | H | M-INTRA (>60 min) |
Patient motion or breathing (instructions) | H | H | H | H | H |
Patient comfort† | M | M | M | M | M |
Inflammation‡ | M | M | M | M | M |
Physical | |||||
Scan acquisition parameters | H | H | H | H | M-INTRA |
Image reconstruction methods, image quality, and quantification | H | H | H | H | M-INTRA |
ROI and VOI | H | H | H | H | H |
SUV normalization | H | H | H | H | H |
Blood glucose level correction | H | H | H | H | H |
Contrast agents used during CT-AC | H | H | H | M | M |
↵* Use of SUV from single scan requires harmonizing standards in all cases.
↵† Patient comfort before and during uptake period and during scanning should meet at least currently accepted recommendations for all patients.
↵‡ Guidelines for correct interpretation and warning about false-positive results due to inflammation should be provided.
H = harmonizing performance standard (including intersubject [or between-subjects] consistency); M-INTRA = minimal performance standard but within-subject consistency of applied methodology; M = minimal performance standard; ROI = region of interest; CT-AC = CT for attenuation correction purposes.