TABLE 1

Biodistribution of ¹¹¹In-DOTA-AR, ⁶⁸Ga-NODAGA-AR, ⁶⁴Cu-CB-TE2A-AR, and ^99mTc-N4-AR in Human PC-3 Tumor–Bearing Nude Mice

Organ	Time after injection (h)^*	¹¹¹In-DOTA-AR	⁶⁸Ga-NODAGA-AR^†	⁶⁴Cu-CB-TE2A-AR	^99mTc-N4-AR
Blood	1	0.21 ± 0.02	0.42 ± 0.30	1.10 ± 0.11	1.20 ± 0.18
	4	0.02 ± 0.001		0.18 ± 0.03	0.27 ± 0.07
	24	0.005 ± 0.001		0.03 ± 0.02	0.04 ± 0.01
Tumor	1	10.56 ± 0.70	7.11 ± 3.26	31.02 ± 3.35	24.98 ± 5.22
	4	8.63 ± 1.13		24.02 ± 2.43	32.85 ± 4.25
	24	3.23 ± 0.52		6.14 ± 0.34	16.55 ± 3.76
Kidneys	1	1.85 ± 0.15	1.13 ± 0.21	6.53 ± 0.52	5.92 ± 0.55
	4	1.38 ± 0.37		1.85 ± 0.32	2.74 ± 0.40
	24	0.24 ± 0.01		0.41 ± 0.07	0.85 ± 0.26
Pancreas	1	10.96 ± 0.57	8.19 ± 2.06	63.31 ± 2.69	66.01 ± 4.86
	4	0.52 ± 0.05		6.01 ± 0.79	11.38 ± 1.44
	24	0.01 ± 0.01		0.12 ± 0.16	0.20 ± 0.08
Muscle	1	0.08 ± 0.02	0.16 ± 0.12	0.34 ± 0.05	0.24 ± 0.05
	4	0.02 ± 0.01		0.19 ± 0.17	0.07 ± 0.02
	24	0.01 ± 0.003		0.05 ± 0.05	0.08 ± 0.07
Intestine	1	1.16 ± 0.24	1.30 ± 0.61	9.47 ± 1.16	6.58 ± 1.04
	4	0.10 ± 0.04		1.76 ± 0.33	1.35 ± 0.37
	24	0.02 ± 0.005		0.14 ± 0.03	0.10 ± 0.06
Liver	1	0.22 ± 0.01	0.19 ± 0.05	4.37 ± 0.30	4.91 ± 0.95
	4	0.09 ± 0.01		2.63 ± 0.64	3.36 ± 0.74
	24	0.03 ± 0.01		0.81 ± 0.06	1.29 ± 0.42
Stomach	1	2.01 ± 0.36	1.26 ± 0.42	9.74 ± 0.45	7.15 ± 0.99
	4	0.56 ± 0.18		4.26 ± 1.51	5.26 ± 0.89
	24	0.01 ± 0.002		0.14 ± 0.16	0.35 ± 0.24
Bone	1	0.16 ± 0.06	0.09 ± 0.03	0.85 ± 0.22	0.82 ± 0.11
	4	0.12 ± 0.04		0.26 ± 0.18	0.41 ± 0.13
	24	0.04 ± 0.02		0.02 ± 0.001	0.18 ± 0.09

↵* Biodistribution data of blocking studies performed at 4 h after injection are provided in Supplemental Table 2.
↵† Biodistribution was performed only at 1 h after injection because of the short half-life of ⁶⁸Ga.
Data are expressed as %IA/g of tissue and are presented as mean ± SD (n = 4–6).