TABLE 1

sst1–sst5 Affinity Profile of 2 Somatostatin Analogs, Compared with SRIF-28 as Reference

Compoundsst1sst2sst3sst4sst5
SRIF-28, reference3.2 ± 0.4 (7)2.4 ± 0.2 (7)4.0 ± 1.1 (7)2.3 ± 0.5 (7)2.3 ± 0.3 (7)
DOTATATE, agonist>1,000 (3)1.5 ± 0.4 (3)>1,000 (3)453 ± 179 (3)547 ± 160 (3)
DOTA-BASS, antagonist>1,000 (4)1.5 ± 0.4 (4)>1,000 (4)287 ± 27 (4)>1,000 (4)
  • Data are expressed as 50% inhibitory concentration in nM (mean ± SEM).

  • Number of experiments are in parentheses.