6 mo (n = 9) | 9 mo (n = 8) | 6 vs. 9 mo (fasting) | 6 vs. 9 mo (insulin) | |||||
Parameter | Fasting | Insulin | Fasting | Insulin | P | Sex-adjusted | P | Sex-adjusted |
Glucose (mmol/L) | 5.0 ± 0.7 | 5.9 ± 0.3 | 4.1 ± 0.1 | 5.2 ± 0.3* | 0.19 | 0.14 | 0.10 | 0.13 |
Insulin (mU/L) | 10 ± 3 | 58 ± 12† | 5 ± 2 | 48 ± 9* | 0.16 | 0.10 | 0.50 | 0.47 |
Glycerol (mg/dL) | 42 ± 7 | 14 ± 3* | 36 ± 7 | 25 ± 10 | 0.58 | 0.50 | 0.18 | 0.20 |
Triglycerides (mg/dL) | 27 ± 6 | 16 ± 4† | 49 ± 5 | 23 ± 6† | 0.011 | 0.018 | 0.37 | 0.37 |
Cholesterol (mg/dL) | 49 ± 4 | 49 ± 4 | 64 ± 6 | 57 ± 5* | 0.043 | 0.044 | 0.24 | 0.23 |
High-density lipoprotein (mg/dL) | 18 ± 2 | 16 ± 2 | 23 ± 1 | 21 ± 1* | 0.059 | 0.079 | 0.088 | 0.11 |
Low-density lipoprotein (mg/dL) | 26 ± 2 | 28 ± 3† | 29 ± 2 | 27 ± 2 | 0.47 | 0.47 | 0.80 | 0.81 |
Aspartate aminotransferase (IU/L) | 29 ± 2 | 43 ± 6‡ | 40 ± 3 | 50 ± 4 | 0.014 | 0.020 | 0.32 | 0.36 |
Alanine aminotransferase (IU/L) | 35 ± 9 | 36 ± 3† | 61 ± 4 | 54 ± 4* | 0.0001 | 0.0002 | 0.001 | 0.002 |
γ-glutamyl transferase (IU/L) | 67 ± 20 | 69 ± 28 | 115 ± 34 | 44 ± 3 | 0.25 | 0.22 | 0.43 | 0.43 |
↵* P ≤ 0.01 vs. fasting state.
↵† P ≤ 0.1 vs. fasting state.
↵‡ P < 0.05 vs. fasting state.
Data were available in maximum of 9 and 8 animals at 6 and 9 mo, respectively, and were pooled in this comparison. P values are shown with and without adding sex as covariate in analysis, showing that there were no sex-related influences.