TABLE 2

Biodistribution of ⁶⁴Cu-NO2A-TFpep Using MDA-MB-435 Tumor–Bearing SCID Mice

	Time
Tissue	0.5 h	1 h	2 h	2-h block	4 h	24 h
Tumor	1.10 ± 0.20	0.90 ± 0.12	0.84 ± 0.06	0.38 ± 0.09^*	0.28 ± 0.04	0.19 ± 0.02
Blood	1.52 ± 0.18	0.33 ± 0.10	0.15 ± 0.02	0.11 ± 0.02	0.12 ± 0.03	0.10 ± 0.02
Brain	0.05 ± 0.01	0.02 ± 0.00	0.01 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.04 ± 0.00
Heart	0.40 ± 0.05	0.16 ± 0.06	0.04 ± 0.01	0.13 ± 0.02	0.04 ± 0.02	0.07 ± 0.02
Lung	2.17 ± 0.23	0.58 ± 0.04	0.43 ± 0.04	0.37 ± 0.04	0.30 ± 0.08	0.27 ± 0.08
Liver	1.87 ± 0.32	1.52 ± 0.12	1.31 ± 0.20	1.30 ± 0.20	1.28 ± 0.08	1.26 ± 0.20
Spleen	0.62 ± 0.11	0.27 ± 0.04	0.32 ± 0.09	0.29 ± 0.02	0.27 ± 0.03	0.30 ± 0.10
Stomach	0.47 ± 0.21	0.23 ± 0.05	0.30 ± 0.05	0.29 ± 0.05	0.29 ± 0.06	0.19 ± 0.07
Kidneys	23.18 ± 4.41	15.38 ± 1.73	14.15 ± 2.30	13.8 ± 1.08	9.37 ± 0.87	2.04 ± 0.64
Muscle	0.30 ± 0.12	0.08 ± 0.01	0.03 ± 0.01	0.03 ± 0.00	0.05 ± 0.03	0.04 ± 0.02
Pancreas	0.51 ± 0.13	0.17 ± 0.07	0.16 ± 0.07	0.12 ± 0.03	0.14 ± 0.08	0.10 ± 0.05
Bone	0.22 ± 0.08	0.17 ± 0.03	0.09 ± 0.04	0.09 ± 0.05	0.02 ± 0.01	0.03 ± 0.00
Intestines	1.28 ± 0.37	0.95 ± 0.07	1.40 ± 0.34	1.30 ± 0.60	1.31 ± 0.35	1.29 ± 0.47
Urine	73.7 ± 8.92	86.9 ± 2.70	90.1 ± 0.64	90.9 ± 1.06	90.4 ± 0.47	94.2 ± 1.15

↵* P = 0.002, significant, compared with ⁶⁴Cu-NO2A-TFpep uptake in absence and presence of its nonradioactive copper-labeled counterpart at 2 h after injection.
Data presented are %ID/g ± SD, except for intestines and urine, which are %ID ± SD (n = 4).