Receiver-Operator-Characteristic Curve Analyses of Lesion and Background SUVmax Data in Table 1
| Tracer | SUVmax Threshold | Specificity | Sensitivity | Distance from perfect marker |
| Bone 18F-FDG | 2.0 | 99.53% | 84.80% | 0.153 |
| Bone 18F-FDHT | 2.6 | 99.13% | 90.04% | 0.100 |
| Soft 18F-FDG | 1.8 | 94.03% | 94.12% | 0.084 |
| Soft 18F-FDHT | 2.3 | 99.47% | 96.94% | 0.031 |
Four distinct tracer- and tissue-dependent threshold values were obtained for optimal discrimination between benign and malignant uptake. For any given threshold, tradeoff exists between sensitivity and specificity. When distance from perfect marker was similar for more than one value, we opted for greater specificity at expense of lower sensitivity.