Biodistribution Data of 89Zr-7E11 Administered Intravenously to Mice Bearing Subcutaneous LNCaP Tumors
| Organ | 24 h (n = 5) | 48 h (n = 5) | 96 h (n = 5) | 120 h (n = 5) | Block (300 μg of mAb) at 48 h (n = 5) |
| Blood | 32.63 ± 4.89 | 23.82 ± 4.34 | 12.37 ± 1.88 | 6.60 ± 2.94 | 17.21 ± 0.83 |
| Heart | 7.33 ± 1.10 | 4.65 ± 1.63 | 3.04 ± 0.61 | 2.95 ± 0.78 | 3.90 ± 0.58 |
| Lungs | 12.84 ± 2.60 | 7.55 ± 2.43 | 7.98 ± 1.46 | 7.79 ± 2.76 | 6.61 ± 0.68 |
| Liver | 53.75 ± 3.83 | 42.74 ± 3.13 | 36.08 ± 2.57 | 32.98 ± 0.65 | 34.14 ± 1.64 |
| Spleen | 28.64 ± 4.44 | 29.90 ± 4.12 | 26.48 ± 2.10 | 31.26 ± 4.04 | 21.36 ± 2.69 |
| Kidney | 27.43 ± 5.13 | 21.61 ± 2.27 | 15.84 ± 3.32 | 15.20 ± 3.38 | 14.82 ± 2.09 |
| Intestine | 3.39 ± 0.66 | 4.91 ± 2.19 | 8.18 ± 4.61 | 1.99 ± 0.29 | 4.56 ± 2.08 |
| Muscle | 1.88 ± 0.51 | 1.02 ± 0.53 | 1.20 ± 0.76 | 0.75 ± 0.18 | 1.24 ± 0.39 |
| Bone | 4.10 ± 0.91 | 6.25 ± 1.32 | 4.52 ± 0.86 | 4.93 ± 1.05 | 4.98 ± 2.19 |
| LNCaP | |||||
| Irradiated | 24.70 ± 7.24 | 40.61 ± 7.51 | 51.79 ± 7.43 | 52.71 ± 11.13 | 8.84 ± 0.89 |
| Control | 20.35 ± 7.50 | 22.82 ± 3.58 | 36.94 ± 6.27 | 25.23 ± 4.82 | 5.93 ± 2.11 |
| Irradiated to blood | 0.76 ± 0.33 | 1.8 ± 0.51 | 4.32 ± 1.21 | 9.86 ± 5.59 | 0.51 ± 0.04 |
| Control to blood | 0.62 ± 0.22 | 0.96 ± 0.21 | 3.02 ± 0.58 | 5.21 ± 2.77 | 0.40 ± 0.03 |
Data are expressed as %ID/g ± SD.