Biodistribution of 68Ga-CPCR4-2 in OH1 Mice at 10, 60, and 120 Minutes After Injection
| Time after injection (min) | ||||
| Organ | 10 (n = 5) | 60 (n = 8) (22) | 120 (n = 3) (22) | 60 (after injection of 50 μg AMD3100; n = 5) |
| Blood | 6.35 ± 0.61 | 1.08 ± 0.27 | 0.58 ± 0.14 | 0.96 ± 0.14 |
| Heart | 3.37 ± 0.39 | 0.60 ± 0.16 | 0.29 ± 0.10 | 0.50 ± 0.07 |
| Lung | 6.75 ± 0.93 | 1.41 ± 0.26 | 2.85 ± 2.69 | 1.41 ± 0.14 |
| Liver | 4.49 ± 0.60 | 1.85 ± 0.24 | 1.48 ± 0.31 | 1.06 ± 0.17 |
| Pancreas | 1.45 ± 0.06 | 0.30 ± 0.07 | 0.21 ± 0.02 | 0.25 ± 0.05 |
| Spleen | 2.54 ± 0.47 | 0.69 ± 0.09 | 0.65 ± 0.25 | 0.43 ± 0.10 |
| Kidney | 14.66 ± 2.07 | 3.06 ± 0.63 | 2.07 ± 0.46 | 2.88 ± 0.45 |
| Adrenal glands | 2.54 ± 1.12 | 0.83 ± 0.55 | 0.50 ± 0.15 | 0.70 ± 0.22 |
| Stomach | 3.45 ± 0.13 | 0.72 ± 0.26 | 0.46 ± 0.12 | 0.82 ± 0.45 |
| Intestine | 1.69 ± 0.15 | 0.45 ± 0.11 | 0.36 ± 0.04 | 0.47 ± 0.13 |
| Muscle | 1.25 ± 0.23 | 0.38 ± 0.09 | 0.28 ± 0.17 | 0.30 ± 0.13 |
| Tumor | 4.55 ± 1.10 | 6.16 ± 1.16 | 4.63 ± 1.54 | 1.35 ± 0.27 |
| Tumor-to-organ ratio | ||||
| Tumor to blood | 0.73 ± 0.21 | 5.81 ± 0.88 | 8.03 ± 2.59 | 1.41 ± 0.25 |
| Tumor to liver | 1.04 ± 0.32 | 3.31 ± 0.32 | 3.06 ± 0.48 | 1.27 ± 0.09 |
| Tumor to kidney | 0.32 ± 0.10 | 2.03 ± 0.19 | 2.36 ± 1.14 | 0.47 ± 0.04 |
| Tumor to muscle | 3.68 ± 0.90 | 16.55 ± 3.84 | 18.49 ± 7.29 | 3.62 ± 0.83 |