TABLE 2

Biodistribution Results and Tumor–to–Normal Tissue Ratios of ⁶⁴Cu- and ⁶⁸Ga-NODAGA-c(RGDfK) in Nude Mice Bearing U87MG Tumors

	⁶⁴Cu				⁶⁸Ga
Organ	1 h	1-h blocking^*	4 h	18 h	1 h	1-h blocking^*
Blood	0.31 ± 0.09	0.15 ± 0.03	0.10 ± 0.03	0.07 ± 0.01	0.16 ± 0.03	0.03 ± 0.01
Heart	0.43 ± 0.04	0.20 ± 0.08	0.29 ± 0.08	0.18 ± 0.04	0.33 ± 0.07	0.03 ± 0.01
Liver	1.67 ± 0.33	0.42 ± 0.14	1.03 ± 0.34	0.58 ± 0.20	1.86 ± 0.23	0.28 ± 0.04
Spleen	1.63 ± 0.42	0.38 ± 0.12	1.02 ± 0.12	0.50 ± 0.11	1.73 ± 0.44	0.15 ± 0.04
Lung	1.08 ± 0.09	0.23 ± 0.01	0.66 ± 0.22	0.38 ± 0.06	0.80 ± 0.07	0.09 ± 0.00
Kidney	2.21 ± 0.27	0.98 ± 0.03	1.57 ± 0.32	0.89 ± 0.23	1.98 ± 0.51	1.07 ± 0.19
Stomach	1.63 ± 0.43	0.49 ± 0.20	0.92 ± 0.20	0.54 ± 0.12	1.40 ± 0.34	0.19 ± 0.09
Intestine	2.12 ± 0.40	0.73 ± 0.19	1.26 ± 0.02	0.95 ± 0.22	1.83 ± 0.51	0.18 ± 0.05
Adrenal	4.67 ± 1.07	0.54 ± 0.15	3.47 ± 0.58	2.78 ± 1.26	5.88 ± 1.06	0.25 ± 0.10
Pancreas	0.53 ± 0.36	0.18 ± 0.09	0.21 ± 0.06	0.16 ± 0.02	0.23 ± 0.08	0.04 ± 0.01
Muscle	0.31 ± 0.03	0.44 ± 0.10	0.16 ± 0.03	0.10 ± 0.02	0.49 ± 0.29	0.07 ± 0.03
Bone	0.58 ± 0.08	0.33 ± 0.11	0.28 ± 0.06	0.34 ± 0.10	0.45 ± 0.21	0.08 ± 0.02
Tumor	3.77 ± 0.52	0.89 ± 0.10	3.62 ± 0.95	3.05 ± 0.62	5.19 ± 1.45	0.41 ± 0.11
Tumor-to-nontumor ratios
Tumor-to-blood	10.15 ± 5.19		36.65 ± 6.46	50.69 ± 8.13	27.67 ± 7.01
Tumor-to-liver	2.67 ± 0.53		3.75 ± 1.07	5.64 ± 1.47	2.75 ± 0.31
Tumor-to-kidney	1.72 ± 0.24		2.37 ± 0.46	3.54 ± 0.67	2.64 ± 0.31
Tumor-to-intestine	1.83 ± 0.46		2.88 ± 0.05	3.42 ± 1.23	2.87 ± 0.49
Tumor-to-muscle	12.16 ± 1.48		23.34 ± 4.41	31.83 ± 3.17	12.80 ± 5.25

↵* Coinjection of c(RGDfV) (5 mg/kg).
Data are %IA/g ± SD (n = 4–7).