TABLE 1

PET Acquisition Schedule

Imaging interval (min from dose)Scan typeLocationAcquisition time per bed position (min)*
−20 (before dosing)TransmissionHead to mid thigh2
0–10†Dynamic emissionUpper chest10 s (repeated)
10–30EmissionHead to mid thigh2
30–50EmissionHead to mid thigh2
50–70EmissionHead to midthigh2
70–100Break——
100–120TransmissionHead to mid thigh2
120–150EmissionHead to mid thigh3
150–180EmissionHead to mid thigh3
180–210Break——
210–230TransmissionHead to midthigh2
230–270EmissionHead to mid thigh5
270–310EmissionHead to mid thigh5

  • * All head–to–mid thigh transmission and emission scans incorporated 7 bed positions.

  • † Zero time (T0) is time of BMS747158 dose administration.