Pharmacokinetic Parameters Based on Well Counting
| Intravenous (n = 14) | IVIG (n = 5) | HAI (n = 6) | ||||
| Pharmacokinetic parameter | Mean ± SD | Median | Mean ± SD | Median | Mean ± SD | Median |
| Co (%ID/L) | 31.9 ± 6.5 | 38.0 ± 9.7 | 29.7 ± 6.0 | |||
| T1/2 (h)* | 65.2 ± 9.8 | 63.9 | 41.6 ± 14.0* | 41.7 | 65.2 ± 9.9 | 68.2 |
| AUC (%ID × h/L) | 3,330 ± 648 | 3,205 | 2,838 ± 699 | 2,772 | 2987 ± 808 | 2,825 |
| Clearance (mL/h) | 31.0 ± 5.6 | 31.2 | 36.8 ± 8.4 | 36.1 | 35.2 ± 8.0 | 35.7 |
| Volume of central compartment (mL) | 3,257 ± 631.2 | 3,221 | 2,758 ± 634 | 2,986 | 3,498 ± 603 | 3,505 |
| Calculated plasma volume (mL) | 2,992 ± 491.9 | 3,171 | 2,935 ± 370 | 2,950 | 3,100 ± 417 | 3,363 |
↵* IVIG T1/2 shorter than intravenous or HAI is significantly different; all other values are not significantly different (Kruskal–Wallis 1-way ANOVA).
Co = estimated initial drug concentration in serum.