Changes Relative to Baseline in Entire Sample with Calibration of PET Scores to ADAS-cog Scale, Signal Strength, and Relative Required Sample Sizes in Clinical Trials
Variable | Mean | SD | Variance | Cohen d | Sample size* |
Change at 6 m | |||||
PET | 0.581 | 2.468 | 6.092 | 0.236 | 120 |
ADAS | 0.466 | 3.589 | 12.883 | 0.130 | 397 |
Change at 12 m | |||||
PET | 1.318 | 2.713 | 7.358 | 0.486 | 28 |
ADAS | 1.167 | 4.510 | 20.339 | 0.259 | 100 |
Change at 24 m | |||||
PET | 2.768 | 3.841 | 14.755 | 0.721 | 13 |
ADAS | 2.622 | 5.981 | 35.773 | 0.438 | 35 |
↵* Relative to 12-mo study using ADAS-cog (set to n = 100).