TABLE 7

Changes Relative to Baseline in Entire Sample with Calibration of PET Scores to ADAS-cog Scale, Signal Strength, and Relative Required Sample Sizes in Clinical Trials

VariableMeanSDVarianceCohen dSample size*
Change at 6 m
 PET0.5812.4686.0920.236120
 ADAS0.4663.58912.8830.130397
Change at 12 m
 PET1.3182.7137.3580.48628
 ADAS1.1674.51020.3390.259100
Change at 24 m
 PET2.7683.84114.7550.72113
 ADAS2.6225.98135.7730.43835
  • * Relative to 12-mo study using ADAS-cog (set to n = 100).