Results from Graphical Analysis and Compartment Modeling of PET Data (ROI Drawn Around Entire Brain)
| Parameter | VT (Logan) | K1/k2 (2TCM) | BPND (k3/k4) (2TCM) | VT (2TCM) |
| Control rats | 1.52 ± 0.18 | 0.62 ± 0.17 | 1.52 ± 0.10 | 1.56 ± 0.37 |
| DPCPX-pretreated | 0.57 ± 0.05 | 0.58 ± 0.07 | 0.00 | 0.58 ± 0.07 |
| P < 0.0001 | P = NS | P < 0.0001 | P < 0.0001 | |
| Ethanol and ABT-702–pretreated | 2.12 ± 0.25 | 0.68 ± 0.17 | 2.34 ± 0.64 | 2.21 ± 0.44 |
| P < 0.005 | P = NS | P < 0.05 | P < 0.05 |
Mean ± SD P values relate to effect of pretreatment, compared with untreated controls.
NS = not significant.