TABLE 2

Biodistribution Data of ¹¹C-MPDX, 80 Minutes After Injection

Tissue	Control animals (n = 5)	DPCPX-pretreated (n = 5)	Difference vs. control	Ethanol and ABT-702–treated (n = 5)	Difference vs. control
Amygdala	0.75 ± 0.09	0.27 ± 0.05	<0.0001	1.12 ± 0.12	<0.0005
Olfactory bulb	0.64 ± 0.18	0.34 ± 0.07	<0.01	0.75 ± 0.27	NS
Cerebellum	1.34 ± 0.29	0.46 ± 0.09	0.0001	2.16 ± 0.42	<0.01
Cingulate	0.88 ± 0.16	0.35 ± 0.08	0.0001	1.13 ± 0.23	0.06
Entorhinal	0.89 ± 0.10	0.37 ± 0.04	<0.0001	1.27 ± 0.25	<0.01
Frontal	0.89 ± 0.20	0.30 ± 0.08	0.0002	1.16 ± 0.26	NS
Hippocampus	1.09 ± 0.14	0.31 ± 0.08	<0.0001	1.47 ± 0.24	0.01
Medulla	0.75 ± 0.18	0.42 ± 0.11	0.01	1.51 ± 0.29	<0.001
Parietal, temporal, and occipital cortex	0.97 ± 0.20	0.34 ± 0.07	0.0001	1.40 ± 0.48	NS
Pons	0.89 ± 0.21	0.44 ± 0.14	<0.01	1.45 ± 0.30	<0.01
Striatum	1.01 ± 0.13	0.31 ± 0.07	<0.0001	1.18 ± 0.31	NS
Bone	0.24 ± 0.04	0.22 ± 0.09	NS	0.24 ± 0.09	NS
Colon	0.83 ± 0.21	0.61 ± 0.19	NS	0.71 ± 0.06	NS
Duodenum	1.12 ± 0.33	0.95 ± 0.57	NS	1.19 ± 0.17	NS
Fat	1.95 ± 1.15	1.52 ± 0.19	NS	1.06 ± 0.24	NS
Heart	0.69 ± 0.14	0.66 ± 0.08	NS	0.85 ± 0.17	NS
Ileum	1.52 ± 0.52	1.19 ± 0.41	NS	1.38 ± 0.43	NS
Kidney	1.09 ± 0.18	1.26 ± 0.07	0.08	1.50 ± 0.50	NS
Liver	2.94 ± 0.40	4.43 ± 1.03	<0.02	3.63 ± 0.68	NS
Lung	0.70 ± 0.09	0.73 ± 0.07	NS	0.88 ± 0.07	<0.01
Muscle	0.40 ± 0.09	0.48 ± 0.07	NS	0.53 ± 0.07	<0.05
Pancreas	0.98 ± 0.18	1.01 ± 0.23	NS	1.48 ± 0.22	<0.005
Plasma	0.77 ± 0.06	0.73 ± 0.13	NS	0.71 ± 0.13	NS
Red cells	0.34 ± 0.04	0.38 ± 0.09	NS	0.44 ± 0.07	<0.02
Spleen	0.95 ± 0.14	0.65 ± 0.06	<0.005	1.06 ± 0.26	NS
Trachea	0.73 ± 0.15	0.81 ± 0.31	NS	0.85 ± 0.23	NS