TABLE 4

Radiation Dose Estimates of ¹⁸F-LBT-999 for Different Organs

	Total dose (mGy/MBq)		Mean total dose (mGy/MBq)
Target organ	Monkey 5	Monkey 6	Mean total dose (mGy/MBq)
Urinary bladder wall	0.088	0.144	0.116
Thyroid	0.088	0.078	0.083
Osteogenic cells	0.075	0.048	0.061
Upper large intestine wall	0.038	0.046	0.042
Small intestine	0.034	0.041	0.038
Kidneys	0.043	0.030	0.036
Brain	0.028	0.023	0.026
Red marrow	0.027	0.018	0.023
Lower large intestine wall	0.017	0.020	0.018
Heart wall	0.020	0.013	0.017
Uterus	0.012	0.015	0.014
Lungs	0.013	0.010	0.012
Gallbladder wall	0.011	0.011	0.011
Ovaries	0.010	0.012	0.011
Spleen	0.010	0.008	0.009
Liver	0.010	0.007	0.008
Total body	0.009	0.008	0.008
Adrenals	0.007	0.005	0.006
Pancreas	0.006	0.005	0.005
Muscle	0.005	0.005	0.005
Stomach wall	0.005	0.004	0.005
Testes	0.004	0.005	0.004
Thymus	0.004	0.003	0.003
Skin	0.003	0.003	0.003
Breasts	0.003	0.002	0.002
ED equivalent (mSv/MBq)	0.027	0.028	0.027
ED (mSv/MBq)	0.021	0.022	0.021