TABLE 3

Biodistribution Results and Tumor–to–Normal Tissue Ratios of ⁶⁴Cu- and ⁶⁸Ga-DOTA-c(RGDfK) in Nude Mice Bearing U87MG Tumors

	⁶⁴Cu			⁶⁸Ga
Organ	1 h	1-h blocking^*	18 h	1 h	1-h blocking^*
Blood	0.63 ± 0.14	0.56 ± 0.23	0.42 ± 0.15	0.38 ± 0.07	0.60 ± 0.14
Heart	1.01 ± 0.21	0.70 ± 0.01	0.93 ± 0.16	0.35 ± 0.08	0.20 ± 0.05
Liver	5.46 ± 1.31	3.14 ± 0.44	2.59 ± 0.81	1.60 ± 0.27	0.48 ± 0.10
Spleen	1.71 ± 0.27	0.73 ± 0.01	1.30 ± 0.27	1.34 ± 0.21	0.36 ± 0.09
Lung	1.58 ± 0.30	2.38 ± 1.07	1.51 ± 0.44	0.87 ± 0.12	0.58 ± 0.11
Kidney	3.31 ± 0.12	2.96 ± 0.31	2.03 ± 0.65	2.24 ± 0.34	1.95 ± 0.68
Stomach	2.65 ± 0.50	1.31 ± 0.32	1.35 ± 0.62	1.50 ± 0.36	0.57 ± 0.11
Intestine	2.79 ± 0.52	1.40 ± 0.32	1.92 ± 0.58	1.79 ± 0.30	0.53 ± 0.08
Adrenal	4.02 ± 1.40	1.03 ± 0.24	2.31 ± 0.72	4.87 ± 1.21	0.71 ± 0.04
Pancreas	0.68 ± 0.08	0.34 ± 0.13	0.53 ± 0.15	0.29 ± 0.05	0.18 ± 0.01
Muscle	0.42 ± 0.08	0.23 ± 0.08	0.23 ± 0.01	0.29 ± 0.04	0.18 ± 0.02
Bone	0.53 ± 0.09	0.51 ± 0.08	0.39 ± 0.14	0.35 ± 0.05	0.11 ± 0.05
Tumor	3.97 ± 0.48	1.57 ± 0.13	3.23 ± 0.75	3.47 ± 0.78	0.89 ± 0.05
Tumor-to-nontumor ratios
Tumor-to-blood	6.46 ± 1.57		8.30 ± 2.58	9.24 ± 1.12
Tumor-to-liver	0.77 ± 0.24		1.35 ± 0.50	2.25 ± 0.37
Tumor-to-kidney	1.20 ± 0.15		1.73 ± 0.65	1.57 ± 0.14
Tumor-to-intestine	1.46 ± 0.29		1.82 ± 0.66	1.95 ± 0.16
Tumor-to-muscles	9.94 ± 3.44		14.30 ± 0.40	12.37 ± 1.81

↵* Coinjection of c(RGDfV) (5 mg/kg).
Data are %IA/g ± SD (n = 4–7).