TABLE 1

⁶⁴Cu-AMD3465 Ex Vivo Biodistribution Studies for Subcutaneous Brain Tumor Xenografts

	Time (min)
Organ/tissue	30	60	90	240	600
Blood	1.93 ± 0.30	0.90 ± 0.08	0.73 ± 0.23	0.61 ± 0.09	1.20 ± 0.36
Heart	1.19 ± 0.16	1.00 ± 0.20	0.90 ± 0.25	0.93 ± 0.06	0.72 ± 0.07
Lung	4.48 ± 0.56	3.70 ± 0.99	2.78 ± 0.47	3.39 ± 0.85	2.10 ± 0.13
Liver	32.08 ± 2.03	35.06 ± 7.77	36.15 ± 1.79	33.65 ± 3.13	27.27 ± 2.57
Stomach	1.91 ± 0.31	2.02 ± 0.76	2.17 ± 0.65	1.98 ± 0.102	1.21 ± 0.03
Spleen	6.23 ± 1.17	5.68 ± 1.75	4.28 ± 1.00	4.88 ± 0.42	2.64 ± 0.12
Kidney	32.45 ± 2.33	32.05 ± 4.03	37.93 ± 3.57	33.57 ± 6.39	25.15 ± 3.29
Small intestines	3.12 ± 0.53	3.33 ± 0.87	2.99 ± 1.01	2.77 ± 0.69	1.79 ± 0.19
Muscle	0.75 ± 0.52	0.37 ± 0.12	0.30 ± 0.13	0.23 ± 0.03	0.19 ± 0.02
Bladder	2.65 ± 0.32	4.75 ± 3.43	2.41 ± 0.51	2.17 ± 0.71	0.96 ± 0.21
Pancreas	1.19 ± 0.18	1.53 ± 0.32	1.13 ± 0.22	1.47 ± 0.62	0.68 ± 0.05
Bone	2.79 ± 0.74	1.53 ± 0.44	1.38 ± 0.19	1.12 ± 0.19	0.80 ± 0.36
Bone marrow	6.39 ± 0.00	10.22 ± 4.97	9.18 ± 2.04	8.10 ± 3.38	9.42 ± 3.88
U87	3.34 ± 0.59	2.56 ± 0.20	4.15 ± 0.94	4.23 ± 1.30	4.03 ± 0.94
U87-stb-CXCR4	106.58 ± 5.99^*	102.70 ± 20.80^*	96.29 ± 13.98^*	50.95 ± 6.38^*	28.92 ± 2.65^*

↵* P < 0.0001, and comparative reference is U87 tumor uptake.