TABLE 1

Pharmacokinetic Parameters of R-¹¹C-Verapamil and ¹¹C-Oseltamivir After Intravenous Administration.

Pharmacokinetic parameter	Infant (9 mo)	Adolescent (24–27 mo)	Adult (5.5–6.8 y)
R-¹¹C-verapamil
C_max,brain (% dose/mL)	0.033 ± 0.007^*	0.020 ± 0.002^†	0.0082 ± 0.0007
T_{max, brain} (min)	1.9 ± 2.2	1.6 ± 1.8	2.2 ± 2.4
CL_uptake,brain (mL/min/g)	0.14 ± 0.04^†	0.087 ± 0.023	0.061 ± 0.011
V_E,brain (mL/g brain)	0.12 ± 0.03^‡	0.069 ± 0.019^*	0.048 ± 0.008
AUC_{brain,0–2.5 min} (% dose × min/g)^§	0.081 ± 0.017	0.049 ± 0.007	0.020 ± 0.002
AUC_{blood,0–2.5 min} (% dose × min/mL)	0.23 ± 0.10	0.20 ± 0.07	0.10 ± 0.01
¹¹C-oseltamivir
C_max,brain (% dose/mL)	0.024, 0.031	0.017, 0.022	0.0062, 0.0086
T_{max, brain} (min)	0.083, 0.25	0.25, 0.25	0.25, 0.25
CL_uptake,brain (mL/min/g)	0.0097, 0.0104	0.0097, 0.0098	0.0072, 0.0079
V_E,brain (mL/g)	0.024, 0.031	0.026, 0.030	0.019, 0.024
AUC_{brain,0–2.5 min} (% dose × min/g)	0.030, 0.034	0.021, 0.026	0.0082, 0.012
AUC_{blood,0–2.5 min} (% dose × min/mL)	0.49, 0.67	0.37, 0.50	0.26, 0.30

↵* Statistically significant age-related difference was observed for some pharmacokinetic parameters (unpaired t test, p < 0.05).
↵† Statistically significant age-related difference was observed for some pharmacokinetic parameters (unpaired t test, p < 0.001).
↵‡ Statistically significant age-related difference was observed for some pharmacokinetic parameters (unpaired t test, p < 0.01).
↵§ A significant age-related difference in AUC_brain (p < 0.05, 1-way ANOVA, Bonferroni's multiple-comparison procedure) was observed.
CL_uptake,brain and V_E,brain were obtained by integration plot analysis using Equation 1.