Characteristics of Cell Lines and Combination Indices of 111In-DTPA-hEGF Plus Trastuzumab or L-788,123
| Cell line characteristic | Combination index (111In-DTPA-hEGF + drug) | ||||
| Cell line | EGFR/cell | HercepTest (Dako)* score or ErbB-2/cell | Ras mutation | Trastuzumab | L-788,123 |
| MDA-MB-468 | 1.3 × 106 | HercepTest 0 (37) | Wild-type K-Ras (38) | 1.65 | 1.34 |
| MDA-MB-231 | 0.5 × 106 | 0.4 × 105 (39) | Mutant K-Ras (38) | 2.5 | 1.36 |
| 231-H2N | 0.2 × 106 | 6.1 × 105 (39) | Mutant K-Ras | <0.47 | <0.45 |
| MCF-7 | 1.0 × 102 | HercepTest 1+ (37) | Wild-type N-Ras overexpression (38,40) | 1 | 4.43 |
↵* HercepTest is an immunohistochemical assay for determination of ErbB-2 protein; scores range from 0 (low ErbB-2) to 3+ (high ErbB-2).