Bone Histomorphometric Parameters in Tibiae
| Parameter | Sham | Ovariectomy |
| Geometric parameters | ||
| Total tissue area (mm2) | 6.28 ± 0.95 | 6.32 ± 0.73 |
| Cortical area (mm2) | 4.66 ± 0.36 | 4.59 ± 0.47 |
| Percentage cortical area (%) | 74.93 ± 7.10 | 72.83 ± 5.55 |
| Medullary area (mm2) | 1.62 ± 0.70 | 1.73 ± 0.48 |
| Percentage medullary area (%) | 25.07 ± 7.10 | 27.17 ± 5.55 |
| Microarchitectural parameters | ||
| Bone volume fraction (%) | 28.75 ± 5.64 | 19.25 ± 2.80* |
| Trabecular thickness (μm) | 58.70 ± 5.15 | 47.91 ± 4.55* |
| Trabecular number (#/mm2) | 4.42 ± 0.36 | 3.35 ± 0.26* |
| Trabecular separation (μm) | 258.94 ± 45.22 | 369.32 ± 52.31* |
| Dynamic parameters | ||
| Mineralizing surface (%) | 6.12 ± 1.22 | 7.97 ± 1.25* |
| Mineral apposition rate (μm/d) | 0.63 ± 0.07 | 0.89 ± 0.14* |
| Bone formation rate (μm3/μm2/d) | 0.039 ± 0.010 | 0.070 ± 0.005* |
Data are expressed as mean ± SD.
↵* P < 0.05 vs. sham.