TABLE 2

Competency Levels 1 and 2: Examples for Domains

	Domain
Competency level	Mathematics and statistics	Imaging physics and instrumentation	Molecular probes and contrast agents	Cell and molecular biology	Biologic model systems	Pharmacology	Clinical imaging of disease
1	Exponential functions	Production of radionuclides	Probe design	Cell processes or structure	Cell culture	Target selection	Modality selection
	Sensitivity and specificity	Interaction of radiation with matter	Coordination chemistry	Metabolic pathways	Animal models, anatomy, physiology	Pharmacokinetics	Probe selection
	Basic descriptive statistics	Detectors	Conjugation chemistry	Molecular biology	Anesthesia, biologic systems	Pharmacodynamics	Imaging methods
	Probability distribution	Formation of images	Quality control	Gene transfer vectors	Imaging and biodistribution	Sampling and analyses	Biomarker metrics
	Nuclear statistics	Imaging modalities	Probe evaluation	Gene therapy	Ethics and compliance	Toxicology	Regulatory
2	Differential equations	x-ray production	Automated synthesis	Gene mapping	Stem cell and trafficking	Pharmacologic classification	Response metrics
	Curve fitting	γ-camera performance	MRI and optical probes	Gene profiling	3-dimensional organ cultures	Receptor interactions	Targeted imaging
	Hypothesis testing	PET performance	Combinatorial chemistry	Protein profiling	Pathophysiology models	Use of radiotracers	Anatomy and physiology
	Power, sample size	Tomographic reconstruction	Synthetic chemistry	Genomics	Animal monitoring	Analyses methods	Informatics
	Survival curves	Image processing	GMP issues; CMC component	Epigenetics	Specialized surgery	IND preparation	Compliance for IND