All cases | Adenocarcinoma | SQC | |||||||
Biomarker | Metastasis (n = 146) | Primary (n = 138) | P | Metastasis (n = 103) | Primary (n = 93) | P | Metastasis (n = 13) | Primary (n = 45) | P |
T/M ratio | 3.25 ± 0.22 | 5.96 ± 0.38 | <0.0001 | 3.42 ± 0.27 | 4.47 ± 0.40 | 0.0281 | 3.67 ± 0.78 | 9.04 ± 0.64 | <0.0001 |
Glut1 | 2.92 ± 0.08 | 2.42 ± 0.09 | <0.0001 | 3.12 ± 0.09 | 2.02 ± 0.09 | <0.0001 | 3.39 ± 0.18 | 3.23 ± 0.09 | 0.4716 |
Glut3 | 1.27 ± 0.05 | 1.30 ± 0.06 | 0.6250 | 1.12 ± 0.04 | 1.29 ± 0.07 | 0.0220 | 1.46 ± 0.22 | 1.33 ± 0.10 | 0.5616 |
Hexokinase I | 2.53 ± 0.09 | 2.81 ± 0.10 | 0.0295 | 2.55 ± 0.09 | 2.49 ± 0.12 | 0.6979 | 3.15 ± 0.32 | 3.45 ± 0.13 | 0.3244 |
HIF-1α | 2.90 ± 0.09 | 3.42 ± 0.11 | 0.0004 | 3.02 ± 0.10 | 2.50 ± 0.12 | 0.0007 | 3.69 ± 0.17 | 4.15 ± 0.15 | 0.1246 |
VEGF | 23.9 ± 1.50 | 30.3 ± 1.70 | 0.0050 | 24.0 ± 1.70 | 24.5 ± 1.80 | 0.8381 | 41.5 ± 5.10 | 44.9 ± 2.70 | 0.5615 |
CD34 | 25.1 ± 0.90 | 24.0 ± 1.10 | 0.4518 | 24.4 ± 1.10 | 20.3 ± 1.30 | 0.0160 | 32.9 ± 2.50 | 31.5 ± 1.30 | 0.6115 |