Labeling of Affibody Molecules
Affibody molecule | Labeling yield (%) | Radiochemical purity after size-exclusion chromatography purification (%) | Stability (loss of label after 1 h of incubation in murine serum at 37°C) (%) |
ZHER2:V1 | 95.5 ± 1.4 | 98.2 ± 1.5 | 2.9 ± 1 |
ZHER2:V2 | 92.0 ± 3.1 | 99.9 ± 0.2 | 3.3 ± 0.1 |
ZHER2:V3 | 97.2 ± 1.4 | 99.6 ± 0.3 | 0 |
ZHER2:V4 | 96.6 ± 0.9 | 99.5 ± 0.2 | 0.05 ± 0.05 |
ZHER2:V5 | 96.2 ± 0.2 | 99.4 ± 0.3 | 0.3 ± 0 |