TABLE 1.

Quantitative (R)-11C-Rolipram Logan Slope and 13N-Ammonia MBF Values for Baseline, Blocked, and Desipramine Challenge Groups

GroupLogan slope (±SD)MBF (±SD)
Baseline, low occupancy (0.00018 mg/kg)5.5 (±0.85)3.5 (±0.60)
Blocked, total PDE4 saturation (>1.0 mg/kg)3.3 * (±0.10)3.9 (±0.61)
Desipramine challenge (0.00018 mg/kg)6.8 † ‡ (±0.70)3.0 (±0.55)

  • ↵* P < 0.01 blocked vs. baseline.

  • ↵† P < 0.001 desipramine vs. baseline.

  • ↵‡ P < 0.001 desipramine vs. blocked.