TABLE 1

Molecular Species of 14C-Phosphatidylcholine Formed in Woodchuck Model of HCC

Phosphatidylethanolamine methylation pathway
Time after injectionCDP-choline pathway (Rf = 0.45–0.50)Rf = 0.30–0.35Rf = 0.15–0.18
HCCs
 12 min80.86 ± 10.45*† (n = 34)11.98 ± 4.75* (n = 34)7.30 ± 8.16† (n = 34)
 30 min95.6 ± 5.4‡ (n = 39)4.4 ± 1.4‡ (n = 39)ND
Surrounding hepatic tissues
 12 min52.6 ± 11.9 (n = 6)ND48.4 ± 12.4 (n = 6)
 30 min100 ± 0 (n = 15)NDND

  • ↵* P < 0.05.

  • ↵† P < 0.05.

  • ↵‡ P < 0.05.

  • ND = Nondetectable.

  • Data are percentage of total 14C-phosphatidylcholine produced (n = sample numbers).